No matter the result, Barca will end the weekend top of the table, but make no mistake this is a tough test for the Blaugrana who have a number of key men missing.
Sergi Roberto’s absence should mean Nelson Semedo starts at right-back, with Valverde having rotated the pair frequently this season.
In the middle Gerard Pique should partner Samuel Umtiti, with both players on four yellow cards and just one booking away from a suspension.
That just leaves Jordi Alba to drop in at left-back with Marc-Andre ter Stegen, of course, between the sticks once again.
And here’s where it gets interesting, as noted already Roberto is out, so is Andre Gomes while Andres Iniesta could be forced out again due to injury.
Barcelona B captain Carles Alena could make the squad and we may see him on the bench for this one.
Despite Luis Suarez’s continued awful form there is no suggestion Valverde is planning on dropping him anytime soon.
The Uruguayan should, therefore take his place alongside Lionel Messi which just leaves one spot up for grabs.
Neither Denis Suarez nor Gerard Deulofeu particularly impressed against Olympiacos, but Deulofeu looks the most likely to get the nod.
Predicted line-up: Ter Stegen; Semedo, Pique, Umtiti, Alba; Paulinho, Busquets, Rakitic; Deulofeu, Messi, Suarez.
Who do you think should start against Sevilla? Let us know your thoughts in the comments below!